In a recent study published in eBioMedicine researchers investigated the dynamic interactions between the gut microbiome and diet particularly their effects on blood glucose homeostasis focusing on variability between individuals.

Their findings provide novel insights into how diet can affect the gut microbiome and blood glucose metabolism at an individual level leading to personalized dietary recommendations promoting metabolic health.

It can be influenced by diet with the microbiome also affecting how the body responds to dietary changes. The gut microbiome contains both beneficial and harmful strains and differs from person to person. Despite this the importance of personalized gut microbiota profiles for mediating the effects of LC and HC diets remains unclear.

To address this the researchers proposed a new study approach the nutritional n-of-1 trial which examines individual responses to diets at a personal level. This design may provide valuable insights into the complex relationship between diet microbiota and metabolism.

The carb-sensitivity score could help personalize dietary recommendations optimizing metabolic health based on an individual’s gut microbiome. The study also validated these findings using machine learning and linear regression models in a broader cohort linking the microbiota with glycemic traits like fasting glucose and HbA1c.

Gut microbiota was found to influence glycemic sensitivity particularly under an HC diet. Principal component analysis (PCA) revealed that certain microbial patterns could predict post-meal blood glucose responses like the maximum glucose spike (MPG) and the duration of high blood sugar.

Source: https://www.news-medical.net/news/20241211/Study-reveals-gut-microbiomee28099s-person-specific-role-in-glycemic-sensitivity.aspx