Global Microbiome Congress

Abstract

The gut micro biome plays a crucial role in maintaining our overall health, and disruption to its composition can lead to a range of health problems. Ostomy creation is a life-saving surgery altering the length of the digestive tract. It is used to treat severe gastrointestinal and medical conditions, including Crohns disease, ulcerative colitis, and colorectal cancer. The understanding of the impact of the differential presence/absence of a colon, as well as the impact of a partial colon on the micro biome and its functional representation, is still nascent.  Our approach focused on comparing microbial and expected function representation in the context of digestive resection and control groups. The population was composed of adults enrolled in a remote nationwide cross-sectional stool-sample collection. The comparison of the ileostomy group and the other two groups allowed us to explore the microbial differences between the small intestine and the colon. The ileostomy micro biome had a distinct alpha and beta diversity compared to the other two groups. These differences in membership extend to the functional representation of pathways. These findings suggest that the complex interplay between the host and intestinal micro biota extends to postbiotics, and may influence the quality of life in ostomies

Biography

Jacques Izard, Ph.D., has been involved for the last 20 years in the human microbiome research field. As the health status of the population is getting more complex, the Izard’s laboratory leverages a multi-disciplinary approach to obtain a greater understanding of our microbiome function to empower everyone to nurture a supportive microbiome