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Asociatia Pronutritie Mures
Title:The Influence of Birth Type on Neonatal Gut Microbiota Diversity
C section birth alters the natural course of intestinal colonization, leading to notable differences in the diversity and abundance of microbial species compared to natural birth. This study aimed to investigate the impact of delivery mode on gut microbial composition during the first three days of life. Fecal samples were collected three days after birth from 49 healthy newborns 34 born vaginally and C section at the neonatology department of the county emergency hospital of tg murex gut micro biota analysis was conducted by sequencing the r-rna gene using the Illumine miseq platform. The study s findings highlight significant differences in the neonatal gut microbiome based on the mode of delivery. Compared to vaginally delivered neonates those born via C section exhibited a markedly lower Shannon index p 0 point 0165, indicating reduced microbial diversity. Additionally, a less balanced microbial community was evidenced by a lower Simpson index p 0 point 0439 in C section-delivered neonates, suggesting a less balanced and stable early gut colonization pattern. Neonates born via C section exhibited a reduced abundance of Bacteroides Lactobacillus, Bifidobacterium and Escherichia coli compared to those born vaginally who showed richer microbial diversity and higher levels of beneficial taxa.These results support the hypothesis that cesarean delivery influences the composition of the gut microbiota, which may have implications for immune development and metabolic health. Further studies are needed to evaluate long-term effects and potential interventions for restoring microbial balance
Pronutrition Association, Targu Mures, Romania, founded in 2013, is dedicated to promoting a healthy lifestyle through balanced nutrition and scientific research. Led by experts in clinical nutrition and molecular biology, the organization has implemented multiple community health programs. The association collaborates with academic and medical institutions to advance knowledge in microbiome studies and nutrigenomics. This study is part of a prevention project, An optimal start in life for your child, which involves a multidisciplinary team made up of neonatologists, pediatricians, nutritionists-dietitians and biologists. Project funded by SNGN ROMGAZ SA